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Of note, Trx2 is localized to the mitochondria and has been found to play an important role in limiting mitochondrial ROS production and regulating cardiac function 10,11

Indeed, MetS, prevalent among obese individuals, often manifests with glucose intolerance, insulin resistance and dyslipidemia (i.e., hypertriglyceridemia and hypercholesterolemia) (Cornier et al., 2008)

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For instance, AAV9-mediated delivery of the very longchain acylCoA dehydrogenase (VLCAD) gene was used to treat very long-chain acyl-CoA dehydrogenase deficiency, directly correcting the -oxidation defect and maintaining stable cardiac function for up to 6 months in mice ( 5.3.2 Stem cell therapy Stem cells possess the remarkable ability to self-renew and undergo multilineage differentiation, enabling them to develop into various cell types such as cardiomyocytes and vascular endothelial cells

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doi: 10.1093/biolre/ioad017 93 SrensenAEWissingMLSalSEnglundALDalgaardLT